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Chronic cough and eosinophilic esophagitis: an uncommon association

Paolo Orizio1, Massimo Cinquini, Stefano Minetti

  • 1Department of Pediatric Surgery, Spedali Civili, Brescia, University of Perugia, Italy.

Case Reports in Gastroenterology
|October 1, 2011
PubMed

Insights

Eosinophilic esophagitis (EE) can cause airway symptoms like chronic cough in children. Patch testing identified cow

Area of Science:

  • Pediatric Gastroenterology
  • Allergy and Immunology
  • Respiratory Medicine

Background:

  • Eosinophilic esophagitis (EE) is increasingly diagnosed in children, often presenting with gastrointestinal issues.
  • A subset of EE patients also experiences airway manifestations, complicating diagnosis and management.

Observation:

  • A 2-year-old child with chronic dry cough initially diagnosed with gastroesophageal reflux disease (GERD).
  • Pathological 24-hour esophageal pH monitoring confirmed GERD.
  • Standard allergy tests were negative, but patch testing revealed cow's milk allergy.

Findings:

  • The case highlights a potential link between GERD and EE in pediatric patients.
  • Patch testing proved effective in diagnosing food allergies, specifically cow's milk allergy, in this case.
  • Airway symptoms in children can be associated with eosinophilic esophagitis and underlying food allergies.

Implications:

  • This case underscores the importance of considering eosinophilic esophagitis in children with persistent airway symptoms, even after a GERD diagnosis.
  • Patch testing may be a valuable tool for allergologic screening in pediatric patients with suspected EE and associated symptoms.
  • Further research into the relationship between GERD, EE, and food allergies is warranted to improve diagnostic and therapeutic strategies.

Keywords:
Chronic coughEosinophilic esophagitisGastroesophageal reflux disease

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