Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neuroplasticity01:01

Neuroplasticity

Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
Plasticity00:58

Plasticity

Plasticity is the property where an object loses its elasticity and undergoes irreversible deformation, even after the deformation forces are eliminated. If a material deforms irreversibly without increasing stress or load, then this is called ideal plasticity. For example, when a force is applied to an aluminum rod, it changes its shape, but it does not return to its original shape once the force is removed. Plastic deformation or ductility is thus a permanent deformation or change in the...
Long-term Potentiation01:25

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when presynaptic neurons...
Long-term Potentiation01:35

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Global daily CO<sub>2</sub> emissions from 1970 to 2024.

Scientific data·2026
Same author

Increasing synchronicity of global extreme fire weather.

Science advances·2026
Same author

The global hydrogen budget.

Nature·2025
Same author

Post-learning replay of hippocampal-striatal activity is biased by reward-prediction signals.

Nature communications·2025
Same author

Emerging climate impact on carbon sinks in a consolidated carbon budget.

Nature·2025
Same author

Hippocampal OLM interneurons regulate CA1 place cell plasticity and remapping.

Nature communications·2025

Related Experiment Video

Updated: May 28, 2026

Acute Mouse Brain Slicing to Investigate Spontaneous Hippocampal Network Activity
07:58

Acute Mouse Brain Slicing to Investigate Spontaneous Hippocampal Network Activity

Published on: August 28, 2020

Ripples make waves: binding structured activity and plasticity in hippocampal networks.

Josef H L P Sadowski1, Matthew W Jones, Jack R Mellor

  • 1MRC Centre for Synaptic Plasticity, School of Physiology and Pharmacology, University of Bristol, University Walk, Bristol BS8 1TD, UK. josef.sadowski@bristol.ac.uk

Neural Plasticity
|October 1, 2011
PubMed
Summary

Hippocampal sharp wave ripples (SWRs) are crucial for memory. These brain events facilitate the replay of neural activity, aiding memory consolidation and synaptic plasticity for better spatial and episodic memory formation.

More Related Videos

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
14:27

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents
11:29

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents

Published on: September 4, 2015

Related Experiment Videos

Last Updated: May 28, 2026

Acute Mouse Brain Slicing to Investigate Spontaneous Hippocampal Network Activity
07:58

Acute Mouse Brain Slicing to Investigate Spontaneous Hippocampal Network Activity

Published on: August 28, 2020

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
14:27

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents
11:29

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents

Published on: September 4, 2015

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Systems Neuroscience

Background:

  • Episodic memory and spatial representation rely on hippocampal processing.
  • Neural network states influence memory encoding and consolidation.
  • Hippocampal sharp wave ripples (SWRs) are implicated in memory consolidation.

Purpose of the Study:

  • To explore the role of SWRs in bridging cellular and network levels of memory processing.
  • To understand how SWRs facilitate the transition from memory encoding to consolidation.
  • To investigate the impact of SWRs on synaptic plasticity and memory formation.

Main Methods:

  • Review of existing literature on hippocampal network oscillations and memory.
  • Analysis of cellular and network mechanisms underlying SWRs.
  • Exploration of the relationship between SWRs, neural replay, and synaptic plasticity.

Main Results:

  • SWRs promote the rapid replay and reactivation of recent neural activity patterns.
  • These reactivation events optimize conditions for synaptic plasticity.
  • SWRs play a vital role in mediating memory consolidation at both cellular and network levels.

Conclusions:

  • SWRs are a key mechanism for memory consolidation in the hippocampus.
  • Understanding SWRs provides insights into the neural basis of episodic and spatial memory.
  • Further research into SWRs can illuminate therapeutic targets for memory disorders.