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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...

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Related Experiment Video

Updated: May 28, 2026

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

Developing an algorithm to convert routine measures of vision into utility values for glaucoma.

Yasmene Alavi1, Mireia Jofre-Bonet, Catey Bunce

  • 1International Centre for Eye Health, London School of Hygiene and Tropical Medicine, London, UK. yasmene.alavi@lshtm.ac.uk

Ophthalmic Epidemiology
|October 4, 2011
PubMed
Summary
This summary is machine-generated.

This study developed algorithms to predict glaucoma patients' quality of life utility values (UVs) using routine clinical data like visual field and acuity. These models offer a practical way to estimate UVs for cost-effectiveness in glaucoma care.

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A Standardized Obstacle Course for Assessment of Visual Function in Ultra Low Vision and Artificial Vision
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A Standardized Obstacle Course for Assessment of Visual Function in Ultra Low Vision and Artificial Vision

Published on: February 11, 2014

Related Experiment Videos

Last Updated: May 28, 2026

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

A Standardized Obstacle Course for Assessment of Visual Function in Ultra Low Vision and Artificial Vision
09:29

A Standardized Obstacle Course for Assessment of Visual Function in Ultra Low Vision and Artificial Vision

Published on: February 11, 2014

Area of Science:

  • Ophthalmology
  • Health Economics
  • Biostatistics

Background:

  • Utility values (UVs) are crucial for cost-effective healthcare decisions in glaucoma management.
  • UVs are infrequently measured in clinical settings, unlike routine visual function tests.
  • There is a need for methods to estimate UVs from readily available clinical data.

Purpose of the Study:

  • To develop an algorithm for calculating utility values (UVs) in glaucoma patients.
  • To predict UVs directly from common clinical measures: binocular visual field, visual acuity, and contrast sensitivity.

Main Methods:

  • 132 primary open-angle glaucoma outpatients participated.
  • Utility values were assessed using the Time Trade-off (TTO) method.
  • Binocular visual acuity (VA(B)), contrast sensitivity (CS(B)), and integrated visual field (IVF) scores were measured; Tobit regression modeled UVs.

Main Results:

  • UVs correlated significantly with clinical measures (IVF, VA(B), CS(B)) and quality of life scores.
  • Two models predicting UVs using IVF and VA(B) explained 22% and 31% of utility variation.
  • Contrast sensitivity (CS(B)) was excluded due to collinearity with visual acuity (VA(B)).

Conclusions:

  • Preliminary algorithms were developed to predict glaucoma patients' UVs from routine clinical outcomes.
  • These models can aid in estimating UVs for cost-effectiveness analyses in glaucoma care.