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Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
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Published on: February 14, 2014

Perimenopause and cognition.

Gail A Greendale1, Carol A Derby, Pauline M Maki

  • 1Division of Geriatrics, David Geffen School of Medicine at UCLA, 10945 Le Conte Avenue, Los Angeles, CA 90095-1687, USA.

Obstetrics and Gynecology Clinics of North America
|October 4, 2011
PubMed
Summary
This summary is machine-generated.

Perimenopause may not cause cognitive decline, but anxiety and depression can negatively impact cognitive function. Estrogen

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Area of Science:

  • Neuroscience
  • Endocrinology
  • Psychology

Background:

  • Perimenopause is a transitional phase with fluctuating hormone levels.
  • Cognitive changes during perimenopause are not fully understood.
  • Mental health symptoms like anxiety and depression are common during this time.

Purpose of the Study:

  • To investigate the impact of perimenopause on cognitive function.
  • To explore the relationship between mood symptoms and cognition during perimenopause.
  • To examine the potential role of estradiol in cognitive changes.

Main Methods:

  • Analysis of data from the Study of Women's Health Across the Nation (SWAN).
  • Assessment of cognitive performance.
  • Evaluation of anxiety and depressive symptoms.

Main Results:

  • No significant cognitive decrement directly attributed to perimenopause was found.
  • Increased anxiety and depressive symptoms independently worsened cognitive performance.
  • Estradiol may offer protection against neurochemical changes affecting cognition.

Conclusions:

  • Cognitive function during perimenopause is more influenced by mood than hormonal decline.
  • The timing of estrogen therapy may be critical for cognitive benefits.
  • Menopausal transition-related cardiovascular risk factors could impact long-term cognitive health.