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Related Concept Videos

Single-Strand DNA Binding Proteins01:03

Single-Strand DNA Binding Proteins

For successful DNA replication, the unwinding of double-stranded DNA must be accompanied by stabilization and protection of the separated single strands of the DNA. This crucial task is performed by single-strand DNA-binding (SSB) proteins. They bind to the DNA in a sequence-independent manner, which means that the nitrogenous bases of the DNA need not be present in a specific order for binding of SSB proteins to it. The binding of SSB proteins straightens single-stranded DNA (ssDNA) and makes...
Lagging Strand Synthesis01:59

Lagging Strand Synthesis

During replication, the complementary strands in double-stranded DNA are synthesized at different rates. Replication first begins on the leading strand. Replication starts later, occurs more slowly, and proceeds discontinuously on the lagging strand.
There are several major differences between synthesis of the leading strand and synthesis of the lagging strand. 1) Leading strand synthesis happens in the direction of replication fork opening, whereas lagging strand synthesis happens in the...
DNA as a Genetic Template02:05

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
DNA Topoisomerases02:02

DNA Topoisomerases

Topoisomerases are enzymes that relax overwound DNA molecules during various cell processes, including DNA replication and transcription. These enzymes regulate positive and negative DNA supercoiling without changing the nucleotide sequence. DNA overwinding in a clockwise direction results in positively supercoiled DNA, whereas underwinding in a counterclockwise direction produces negatively supercoiled DNA.
Types and Mechanism of action
Topoisomerases are divided into two main types.  Type I...
The DNA Replication Fork01:02

The DNA Replication Fork

An organism’s genome needs to be duplicated in an efficient and error-free manner for its growth and survival. The replication fork is a Y-shaped active region where two strands of DNA are separated and replicated continuously. The coupling of DNA unzipping and complementary strand synthesis is a characteristic feature of a replication fork.   Organisms with small circular DNA, such as E. coli, often have a single origin of replication; therefore, they have only two replication forks, one in...
The DNA Replication Fork01:02

The DNA Replication Fork

An organism’s genome needs to be duplicated in an efficient and error-free manner for its growth and survival. The replication fork is a Y-shaped active region where two strands of DNA are separated and replicated continuously. The coupling of DNA unzipping and complementary strand synthesis is a characteristic feature of a replication fork.   Organisms with small circular DNA, such as E. coli, often have a single origin of replication; therefore, they have only two replication forks, one in...

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DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
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Spin specific electron conduction through DNA oligomers.

Zuoti Xie1, Zouti Xie, Tal Z Markus

  • 1Department of Chemical Physics, Weizmann Institute of Science, Rehovot 76100, Israel.

Nano Letters
|October 4, 2011
PubMed
Summary
This summary is machine-generated.

Researchers demonstrate that double-stranded DNA oligomers exhibit spin selectivity, creating a true organic spin filter. This finding, exceeding current systems at room temperature, highlights spin

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Area of Science:

  • Spintronics
  • Organic electronics
  • Molecular magnetism

Background:

  • Spintronics and its devices predominantly utilize inorganic magnetic materials.
  • Existing organic spintronics devices rely on inorganic ferromagnetic electrodes for spin selectivity.
  • The magnetoresistance effect has been observed in organic materials, but intrinsic molecular spin selectivity was lacking.

Purpose of the Study:

  • To demonstrate intrinsic spin selectivity in organic molecules.
  • To investigate conduction properties of double-stranded DNA oligomers.
  • To establish DNA as a potential component for organic spintronics.

Main Methods:

  • Fabrication and electrical characterization of devices utilizing double-stranded DNA oligomers.
  • Measurement of spin-dependent resistivity at room temperature.
  • Analysis of conduction mechanisms, distinguishing from atomic spin-orbit coupling.

Main Results:

  • Conduction through double-stranded DNA oligomers is intrinsically spin selective.
  • The observed spin selectivity surpasses that of any known system at room temperature.
  • Spin-dependent resistivity suggests a unique property related to chirality symmetry, not solely atomic spin-orbit coupling.

Conclusions:

  • Double-stranded DNA oligomers function as a true organic spin filter.
  • Chirality symmetry in DNA plays a crucial role in its spin-selective electron transport.
  • These findings suggest the potential importance of spin phenomena in biological electron transfer.