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Genetic analysis of polymorphic proteins of the human malaria parasite Plasmodium falciparum

B Fenton1, D Walliker

  • 1Department of Genetics, University of Edinburgh, Scotland, U.K.

Genetical Research
|April 1, 1990
PubMed

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Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...