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Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
Previous stillbirth, late preterm, and early-term birth
1Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, UT 84132, USA. robert.silver@hsc.utah.edu
Subsequent pregnancies are emotionally traumatic for families with previous stillbirths. Such pregnancies have a 2- to 10-fold increase in the risk for stillbirth as well as an increased probability of other adverse obstetrical outcomes. These medical risks as well as anxiety on the part of families and care providers contribute to an increase in late preterm and early-term birth. However, delivery before 39 weeks' gestation has not been proven to reduce the risk of recurrent stillbirth or adverse pregnancy outcomes in women with previous stillbirths. This work reviews data regarding the optimal timing of delivery in subsequent pregnancies after previous stillbirth, as well as for patients at risk from stillbirth in general. Management recommendations from current data are presented and knowledge gaps are highlighted.
Subsequent pregnancies are emotionally traumatic for families with previous stillbirths. Such pregnancies have a 2- to 10-fold increase in the risk for stillbirth as well as an increased probability of other adverse obstetrical outcomes. These medical risks as well as anxiety on the part of families and care providers contribute to an increase in late preterm and early-term birth. However, delivery before 39 weeks' gestation has not been proven to reduce the risk of recurrent stillbirth or adverse pregnancy outcomes in women with previous stillbirths. This work reviews data regarding the optimal timing of delivery in subsequent pregnancies after previous stillbirth, as well as for patients at risk from stillbirth in general. Management recommendations from current data are presented and knowledge gaps are highlighted.
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