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Related Experiment Videos

H-ras protooncogene mutations in human thyroid neoplasms.

H Namba1, R A Gutman, K Matsuo

  • 1Department of Medicine, Cedars-Sinai Medical Center, University of California School of Medicine, Los Angeles 90048.

The Journal of Clinical Endocrinology and Metabolism
|July 1, 1990
PubMed
Summary

Mutations in the H-ras protooncogene were found in both benign and malignant thyroid tumors. These alterations, including gene amplification and point mutations, suggest a role for H-ras in thyroid neoplasm development.

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Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Protooncogene alterations are implicated in human neoplasm pathogenesis.
  • Thyroid tumors encompass a range of benign and malignant conditions.
  • Ras protooncogenes are critical regulators of cellular processes.

Purpose of the Study:

  • To investigate structural alterations in specific protooncogenes within thyroid tumors.
  • To identify the role of H-ras protooncogene mutations in thyroid neoplasm development.
  • To explore the correlation between H-ras alterations and thyroid tumor characteristics.

Main Methods:

  • Screening of 54 thyroid tumors (36 benign, 18 malignant) for gene rearrangements.
  • Analysis of protooncogenes including c-myc, c-myb, c-fos, c-erb-B1, c-erb-B2, c-erb-A, N-ras, K-ras, and H-ras.

Related Experiment Videos

  • Detection of H-ras mutations, gene amplification, and polymorphisms using molecular techniques.

    • Main Results:

    • H-ras mutations were observed in 4 benign and 4 malignant thyroid neoplasms; none found in colloid adenomas.
    • Gene amplification of H-ras was detected in 5 tumors, including a papillary carcinoma with a truncated, mutated allele.
    • H-ras polymorphisms and allele loss were also identified in specific thyroid tumors.

    Conclusions:

    • Ras protooncogenes can transform via quantitative (increased expression) or qualitative (activating point mutations) mechanisms.
    • Both quantitative and qualitative H-ras alterations coexist in thyroid neoplasms.
    • A combination of H-ras mutation types may contribute to a broader spectrum of neoplastic phenotypes in thyroid cancer.