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Stenosis of the Inferior Vena Cava: A Murine Model of Deep Vein Thrombosis
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Superficial thrombophlebitis. I. Primary hypercoagulable states

C P Samlaska1, W D James

  • 1Dermatology Service, Walter Reed Army Medical Center, Washington, D.C.

Journal of the American Academy of Dermatology
|June 1, 1990
PubMed

This review concentrates on those disorders in which superficial thrombophlebitis can be a significant or presenting clinical sign. Primary hypercoagulable states are those conditions associated with an increased risk of thrombosis caused by a specific measurable defect in the proteins of coagulation and/or fibrinolytic systems. These disorders are frequently inherited and include deficiencies of antithrombin III, heparin cofactor 2, protein C, protein S, abnormal fibrinolytic activity, dysfibrinogenemia, and Hageman trait. Patients with a lupus anticoagulant and anticardiolipin antibody syndrome with thrombotic episodes are also considered to have a primary hypercoagulable state. The physiology, pathophysiology, clinical characteristics, and treatment of primary hypercoagulable states are reviewed.

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