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Related Experiment Video

Updated: May 28, 2026

Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation

Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation

Published on: November 7, 2020

Liver transplantation and hepatitis C.

A Rubín¹, V Aguilera, M Berenguer

¹Hepatology-liver transplantation unit, Digestive medicine service, and Ciberehd, National network center for hepatology and gastroenterology research, Hospital Universitari i Politècnic La Fe, Instituto de Salud Carlos III, Bulevar Sur s/n, 46026 Valencia, Spain.

Clinics and Research in Hepatology and Gastroenterology

|October 4, 2011

Summary

Hepatitis C virus (HCV) recurrence after liver transplant leads to graft disease. Antiviral therapy can improve outcomes, but monitoring and treatment selection are crucial for managing post-transplant HCV.

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Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation

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Published on: November 7, 2020

Intrasplenic Transplantation of Hepatocytes After Partial Hepatectomy in NOD.SCID Mice

Intrasplenic Transplantation of Hepatocytes After Partial Hepatectomy in NOD.SCID Mice

Published on: February 10, 2018

Area of Science:

Hepatology
Transplant Surgery
Virology

Background:

Hepatitis C virus (HCV) is a leading cause of liver transplantation.
HCV recurrence post-transplant (graft re-infection) is common and leads to graft disease.
Graft re-infection can cause cirrhosis in 20-30% and graft failure in 10% within 5-10 years.

Purpose of the Study:

To review the impact of HCV recurrence on liver transplant outcomes.
To discuss the role of antiviral therapy and monitoring in managing recurrent HCV.
To outline retransplantation as a last resort for graft failure.

Main Methods:

Review of current literature on HCV recurrence after liver transplantation.
Analysis of outcomes associated with antiviral therapy.
Discussion of diagnostic and monitoring tools for recurrent hepatitis C.

Main Results:

Antiviral therapy, especially with sustained viral response, improves graft histology and outcomes.
Peginterferon with ribavirin achieves sustained viral response in ~35% of patients.
Side effects of antiviral therapy are frequent, and retransplantation is an option for graft failure.

Conclusions:

Effective management of HCV recurrence is vital for long-term liver transplant success.
Monitoring and timely antiviral treatment are essential to prevent graft failure.
Optimizing donor organ quality and exploring new therapies are important for improving transplant outcomes.