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Maintaining CD4-CD8 lineage integrity in T cells: where plasticity serves versatility

Lie Wang1, Yumei Xiong, Rémy Bosselut

  • 1Laboratory of Immune Cell Biology, Center for Cancer Research (CCR), NCI, NIH, Bethesda, MD 20892-4259, USA.

Seminars in Immunology
|October 4, 2011
PubMed
Summary

T cell differentiation involves CD4+ or CD8+ lineage commitment in the thymus. Transcription factors and epigenetic mechanisms maintain these T cell lineages while allowing effector functions.

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