Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Synaptic Signaling01:09

Synaptic Signaling

Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
Neuroplasticity01:01

Neuroplasticity

Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
Long-term Potentiation01:25

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when presynaptic neurons...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A three-groups non-local model for combining heterogeneous data sources to identify genes associated with Parkinson's disease.

Biometrics·2026
Same author

Developmental transcriptomic analysis of cultured primary mouse cortical neurons reveals sex-specific expression of neuropeptides.

bioRxiv : the preprint server for biology·2026
Same author

Predictive Cellular Signatures from Live Human Motor Neurons Distinguish TDP-43 ALS and Enable ALS Subtype Stratification.

bioRxiv : the preprint server for biology·2026
Same author

Mechanisms controlling the deposition and dynamics of histone variant H2BE.

bioRxiv : the preprint server for biology·2026
Same author

Survey of the human proteostasis network: the ubiquitin-proteasome system.

bioRxiv : the preprint server for biology·2026
Same author

Neurogenin-2 Reprograms Human Microglial Lineage Cells into Neurons In Vitro and in Chimeric Brains.

bioRxiv : the preprint server for biology·2026
Same journal

Brain rhythms of depression: A predictive processing perspective.

Trends in neurosciences·2026
Same journal

Building neuroscience capacity in low- and middle-income countries: Lessons from Ghana.

Trends in neurosciences·2026
Same journal

Emulating the periodic table: A unified list of CNS terms and abbreviations for humans and experimental animals.

Trends in neurosciences·2026
Same journal

From chromatin dynamics to brain disease: Polycomb-Trithorax mechanisms in neurodevelopment.

Trends in neurosciences·2026
Same journal

Striatum regulates the cortex via the basal forebrain cholinergic system: A role for substance P.

Trends in neurosciences·2026
Same journal

A large brain adds new types of neurons: Molecular and functional signatures of spindle neurons in the human neocortex.

Trends in neurosciences·2026
See all related articles

Related Experiment Video

Updated: May 28, 2026

3D Modeling of Dendritic Spines with Synaptic Plasticity
07:13

3D Modeling of Dendritic Spines with Synaptic Plasticity

Published on: May 18, 2020

Arc in synaptic plasticity: from gene to behavior.

Erica Korb1, Steven Finkbeiner

  • 1Gladstone Institute of Neurological Disease, San Francisco, CA, USA.

Trends in Neurosciences
|October 4, 2011
PubMed
Summary
This summary is machine-generated.

The activity-regulated cytoskeletal protein (Arc) is crucial for memory consolidation and synaptic plasticity. Understanding Arc regulation offers insights into neuronal activity, memory, and neurological diseases.

More Related Videos

Implantation of a Cranial Window for Repeated In Vivo Imaging in Awake Mice
06:33

Implantation of a Cranial Window for Repeated In Vivo Imaging in Awake Mice

Published on: June 22, 2021

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents
11:29

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents

Published on: September 4, 2015

Related Experiment Videos

Last Updated: May 28, 2026

3D Modeling of Dendritic Spines with Synaptic Plasticity
07:13

3D Modeling of Dendritic Spines with Synaptic Plasticity

Published on: May 18, 2020

Implantation of a Cranial Window for Repeated In Vivo Imaging in Awake Mice
06:33

Implantation of a Cranial Window for Repeated In Vivo Imaging in Awake Mice

Published on: June 22, 2021

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents
11:29

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents

Published on: September 4, 2015

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • The activity-regulated cytoskeletal (Arc) protein is essential for memory consolidation.
  • Arc plays a vital role in synaptic plasticity and neuronal function.
  • Dysregulation of Arc is linked to neurological disorders.

Purpose of the Study:

  • To review the regulation of the Arc gene and protein.
  • To explore Arc's molecular functions in synaptic plasticity.
  • To discuss Arc's role in behavior, disease, and identify research gaps.

Main Methods:

  • Literature review of Arc gene and protein regulation.
  • Analysis of Arc's molecular mechanisms in synaptic plasticity.
  • Synthesis of current knowledge on Arc's role in neuroscience.

Main Results:

  • Neuronal activity tightly controls Arc mRNA and protein.
  • Arc mediates multiple forms of synaptic plasticity.
  • Arc is implicated in memory formation and neurological diseases.

Conclusions:

  • Arc is a key regulator of synaptic plasticity and memory.
  • Further research into Arc regulation and function is critical for understanding brain function and disease.
  • Arc serves as a valuable tool for studying neuronal activity.