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Updated: May 28, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
[Dapsone for chronic skin lesions in 3 children suffering from Henoch-Schönlein vasculitis]
N Mazille1, D Lipsker, M Fischbach
1Service de pédiatrie-1, hôpital de Hautepierre, CHRU de Strasbourg, 67098 Strasbourg, France.
Abstract:
We describe 3 cases of chronic purpuric skin lesions in children suffering from systemic vasculitis: 3 children with Henoch-Schönlein purpura. Dapsone was introduced when skin lesions were recurrent, extensive, and persistent, due to its known ability to act as an anti-IgA and as an anticytotoxic agent against polynuclear neutrophils. Fast and complete but purely suspensive healing of skin lesions was noted. One child developed methemoglobinemia, a known side-effect of dapsone, highlighting the need for adequate prescription and follow-up.
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