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Relationship between circulating cytokine levels and physical or psychological functioning in patients with advanced

Takeshi Ishikawa¹, Satoshi Kokura, Naoyuki Sakamoto

¹Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Clinical Biochemistry

|October 4, 2011

Abstract

Objective:

To investigate the relation between functional impairments of cancer patients and circulating cytokines using a multiplex technique.

Design And Methods:

50 patients with cancer were assessed using the quality of life (QOL) questionnaire. 27 plasma cytokine levels were determined by using the Bio-Plex array system. The relation to QOL scores was assessed using Chi-square test for categorical variables and univariate linear regression analysis for cytokine levels.

Results:

Multivariate analysis showed that interleukin-6 (IL-6) level is a significant independent determinant of physical (β=-0.238, P=0.0126) and cognitive functioning (β=-0.462, P=0.0006) and that vascular endothelial growth factor (VEGF) level is a significant independent determinant of emotional functioning (β=-0.414, P=0.039).

Conclusion:

This study, in which 27 cytokines are simultaneously tested with cutting edge technology, demonstrates that plasma IL-6 and VEGF are significant independent determinants of functional impairments in patients with cancer.

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