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Rapid Fabrication of Custom Microfluidic Devices for Research and Educational Applications
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Microfluidic devices: useful tools for bioprocess intensification.

Marco P C Marques1, Pedro Fernandes

  • 1Department of Bioengineering, Instituto Superior Técnico, Universidade Técnica de Lisboa, Av Rovisco Pais, 1049-001 Lisboa, Portugal.

Molecules (Basel, Switzerland)
|October 4, 2011
PubMed
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Microfluidic devices are increasingly used for process intensification in biotechnology, mirroring chemical engineering trends. This review covers microreactor designs, downstream processing, and engineering challenges for scalable applications.

Area of Science:

  • Biotechnology
  • Chemical Engineering
  • Process Intensification

Background:

  • Microfluidic devices have gained prominence in biotechnology for process intensification.
  • This trend aligns with established microfluidic applications in chemical engineering, including production-scale use.
  • Research output in microfluidics for biotechnology has shown consistent growth.

Purpose of the Study:

  • To provide an updated overview of microfluidic devices for process intensification in biotechnology.
  • To focus on microreactor designs, configurations, and operational modes.
  • To include downstream processing applications and engineering considerations.

Main Methods:

  • Review of current literature on microfluidic devices in biotechnology.

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  • Analysis of engineering considerations, fluid dynamics, and micromixing.
  • Discussion of analytical requirements and implementation strategies.

    • Main Results:

    • Microfluidic devices offer significant potential for process intensification in biotechnology.
    • Key aspects include microreactor design, flow characterization, and micromixing.
    • Implementation strategies and analytical requirements are crucial for success.

    Conclusions:

    • Microfluidics is a vital tool for advancing process intensification in biotechnology.
    • Engineering and fluid dynamics are critical for optimizing microfluidic systems.
    • Future developments will likely focus on overcoming current limitations and enhancing scalability.