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Chemo-enzymatic Synthesis of N-glycans for Array Development and HIV Antibody Profiling
Published on: February 5, 2018
Synthesis of new Galβ1→4Fuc segments useful for biological investigations
Kazusa Nishiyama1, Atsushi Yamada, Tomoharu Takeuchi
1School of Pharmaceutical Sciences, Teikyo University, Kanagawa, Japan.
Chemical & Pharmaceutical Bulletin
|October 4, 2011
Abstract:
Useful segments (1, 2) for chemical probes embedded in a Galβ1→4Fuc unit were designed and prepared for characterizing sugar-binding proteins in Caenorhabditis elegans. Segment 1 with an amino group terminus was used as a recognition unit in affinity chromatography. It was revealed that some proteins (annexins and galectins) in C. elegans have an affinity for Galβ1→4Fuc.
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