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Leukoencephalopathy induced by low-dose methotrexate in a patient with rheumatoid arthritis
Masayuki Matsuda1, Dai Kishida, Tomomi Kinoshita
1Department of Medicine (Neurology and Rheumatology), Shinshu University School of Medicine, Japan. matsuma@shinshu-u.ac.jp
Abstract:
We report a patient with rheumatoid arthritis (RA) who developed leukoencephalopathy while being treated with low-dose methotrexate (MTX). She suddenly developed loss of recent memory and left homonymous hemianopsia ascribable to the bilateral but right-predominant occipitotemporal lesions. Intravenous administration of dexamethasone and cessation of MTX quickly relieved her clinical symptoms. Low-dose MTX-induced leukoencephalopathy is a rare complication in RA, but is important with regard to the possibility of serious neurological sequellae.
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