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Updated: May 28, 2026
11:17
Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
[Safety profile of antimicrobial agents]
1Department of Pharmacology, Jikei University School of Medicine, Tokyo, Japan. horis@jikei.ac.jp
Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan
|October 4, 2011
Summary
New quinolone antibiotics can cause convulsions, an effect worsened by anti-inflammatory drugs. Some quinolones also affect blood glucose levels, highlighting the need for understanding antibiotic safety profiles.
Area of Science:
- Pharmacology
- Microbiology
- Toxicology
Context:
- Antibiotics are crucial for treating infectious diseases.
- Adverse effects of antibiotics are known but often mechanistically unclear.
- New quinolones exhibit specific toxicities, including convulsions and effects on glucose metabolism.
Purpose:
- To investigate the adverse effects of new quinolone antibiotics.
- To characterize the interaction between new quinolones and anti-inflammatory drugs regarding convulsant activity.
- To assess the impact of specific new quinolones on blood glucose levels.
Summary:
- New quinolones possess individual convulsant activities, which can be potentiated by co-administration with anti-inflammatory drugs.
- Enoxacin, lomefloxacin, and gatifloxacin demonstrably reduce blood glucose levels in a dose-dependent manner.
- Ciprofloxacin and levofloxacin did not exhibit significant effects on blood glucose levels in reported cases.
Impact:
- Highlights the importance of understanding the distinct safety profiles of individual new quinolone antibiotics.
- Emphasizes the need for caution when prescribing new quinolones concurrently with anti-inflammatory agents.
- Informs clinical decision-making regarding the safe use of antimicrobial agents in patients with infectious diseases.
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