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Updated: May 28, 2026

Ultrasonographic Evaluation of Salivary Glands for Sjogren's Syndrome: Diagnostic and Monitoring Insights
Published on: October 13, 2023
[Sjögren's syndrome and non-Hodgkin's lymphoma: from pathophysiology to treatment]
Véronique Le Guern1, Luc Mouthon
1Assistance Publique-Hôpitaux de Paris, université Paris-Descartes, hôpital Cochin, pôle de médecine interne, Paris, France. veronique.le-guern@cch.aphp.fr
Abstract:
Although infrequent, the development of non-Hodgkin's lymphoma (NHL) during the course of Sjögren's syndrome represents a major complication. Nethertheless, most NHL developing in patients with Sjögren's syndrome are B cell lymphomas involving the marginal zone, localized to extranodal sites. Predictive factors include lymphadenopathy, splenomegaly, neutropenia, cryoglobulinemia and low C4 levels. The treatment of B cell lymphomas depends on its nature and localization. Biotherapies targeting the B lymphocyte, such as rituximab, a chimeric monoclonal anti-CD20 antibody, or more recently targeting BAFF can be proposed.
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