Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ionizing radiation and the developing brain.

W J Schull1, S Norton, R P Jensh

  • 1Center for Demographic and Population Genetics, University of Texas Health Science Center, Houston 77225.

Neurotoxicology and Teratology
|May 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ultraviolet radiation exposure to the face in patients with xeroderma pigmentosum and healthy controls: applying a novel methodology to define photoprotection behaviour.

The British journal of dermatology·2021
Same author

Describing the burden of the COVID-19 pandemic in people with psoriasis: findings from a global cross-sectional study.

Journal of the European Academy of Dermatology and Venereology : JEADV·2021
Same author

Risk-mitigating behaviours in people with inflammatory skin and joint disease during the COVID-19 pandemic differ by treatment type: a cross-sectional patient survey.

The British journal of dermatology·2020
Same author

The 2020 International Alliance for the Control of Scabies Consensus Criteria for the Diagnosis of Scabies.

The British journal of dermatology·2020
Same author

Secular changes in functional disability, pain, fatigue and mental well-being in early rheumatoid arthritis. A longitudinal meta-analysis.

Seminars in arthritis and rheumatism·2019
Same author

Depressive symptoms in inflammatory bowel disease: an extraintestinal manifestation of inflammation?

Clinical and experimental immunology·2019

The central nervous system is uniquely susceptible to radiation due to its developmental stage and cellular vulnerability. Research compares human and animal data on radiation-induced behavioral changes, highlighting the need for further study on low-dose prenatal radiation effects.

Area of Science:

  • Neuroscience
  • Radiation Biology
  • Developmental Biology

Background:

  • The central nervous system (CNS) exhibits unique susceptibility to radiation due to its prolonged development, vulnerable neuronal cells, cell migration, limited neuron regeneration, and complexity.
  • Radiation exposure can induce CNS damage through cell death, disrupted migration, impaired neural connections, and altered dendritic development, leading to behavioral changes.

Purpose of the Study:

  • To review and compare human and animal behavioral data following radiation exposure.
  • To assess the utility of behavioral tests in detecting prenatal radiation effects.
  • To identify knowledge gaps regarding low-dose prenatal ionizing radiation impacts on postnatal development.

Main Methods:

  • Comparative analysis of existing human and animal behavioral data.

Related Experiment Videos

  • Review of studies utilizing neonatal and postnatal behavioral tests as indicators of radiation effects.

    • Main Results:

    • Mammalian species show similar radiation sensitivity when developmental periods are compared.
    • Neonatal and postnatal behavioral tests are sensitive, noninvasive measures for prenatal radiation exposure.
    • The predictive validity of these tests for human outcomes remains uncertain.

    Conclusions:

    • Prenatal radiation exposure can cause structural CNS alterations that manifest as behavioral changes.
    • Further research is required to understand the long-term effects of low-dose prenatal ionizing radiation on CNS morphology and function.