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Adenovirus vaccine strains genetically engineered to express HIV-1 or HBV antigens for use as live recombinant
P P Hung1, P K Chanda, R J Natuk
1Wyeth-Ayerst Research, Philadelphia, Pa.
Natural Immunity and Cell Growth Regulation
|January 1, 1990
Abstract:
Types 4 and 7 adenovirus are currently used as live, oral vaccines for the prevention of adenovirus respiratory disease in military recruits. These vaccine strains have been genetically engineered in order to express HIV-1 or HBV antigens in infected cells. A dog model was developed to evaluate the immunogenicity of these recombinant vaccines. Dogs inoculated with live adenovirus-HBV recombinant vaccine produced antibody against hepatitis B surface antigen.