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Dynamic physostigmine effects on hippocampus perfusion.

Xiufeng Li1, Jeffrey S Spence, David M Buhner

  • 1Radiology, UT Southwestern Medical Center, Dallas, Texas 75390-8896, USA.

Journal of Magnetic Resonance Imaging : JMRI
|October 4, 2011
PubMed
Summary
This summary is machine-generated.

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A 20-minute physostigmine infusion effectively reduces hippocampus blood flow, detectable with arterial spin labeling (ASL) for up to an hour, minimizing side effects.

Area of Science:

  • Neuroimaging
  • Pharmacology
  • Cardiovascular Physiology

Background:

  • Physostigmine is a reversible cholinesterase inhibitor with potential applications in neurological conditions.
  • Understanding its effects on cerebral blood flow is crucial for therapeutic development.
  • Arterial spin labeling (ASL) offers a non-invasive method to assess brain perfusion.

Purpose of the Study:

  • To characterize the dynamic response of hippocampus blood flow to physostigmine infusion.
  • To determine an optimal infusion duration for robust ASL detection of effects.
  • To identify an infusion time short enough to avoid peripheral side effects.

Main Methods:

  • ASL perfusion imaging was used in 11 subjects (2 female, 9 male) aged 49-53 years.
  • The study involved a 20-minute baseline, 30-minute physostigmine infusion (1.0 mg/hr), and a 70-minute recovery period.

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  • Time course of hippocampus blood flow changes was analyzed.

    • Main Results:

    • Hippocampus perfusion decreased significantly after 20 minutes of physostigmine infusion.
    • Blood flow reached its lowest point near the end of infusion and remained stable during recovery.
    • A consistent reduction of approximately 13.4% in bilateral hippocampus perfusion was observed.

    Conclusions:

    • A 20-minute physostigmine infusion at 1.0 mg/hr is sufficient to induce significant changes in hippocampus blood flow.
    • Perfusion imaging up to 60 minutes post-infusion can detect these effects.
    • This approach minimizes the risk of adverse physostigmine side effects.