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Updated: May 28, 2026

Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
Published on: May 26, 2022
Improvement of sodium status to optimize the efficacy of Renin-Angiotensin system blockade
Gozewijn D Laverman1, Gerjan Navis
1Department of Internal Medicine, Division of Nephrology, ZGT Hospital Almelo, Almelo, The Netherlands.
Abstract:
Blockade of the renin-angiotensin-aldosterone system (RAAS) offers superior renoprotection in the treatment of patients with hypertension, but the efficacy of RAAS inhibition strongly depends on sodium status, presumably in relation to extracellular volume status. Because assessing volume status by physical examination is challenging, 24-hour urine collection and NT-proBNP levels are useful tools for guiding volume management and achieving sodium status targets.
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