Related Experiment Video

Updated: May 28, 2026

Characterization of G Protein-coupled Receptors by a Fluorescence-based Calcium Mobilization Assay
11:49

Characterization of G Protein-coupled Receptors by a Fluorescence-based Calcium Mobilization Assay

Published on: July 28, 2014

Electrophysiological analysis of G protein-coupled receptors in mammalian neurons

W R Proctor1, T V Dunwiddie

  • 1Veterans Administration Medical Research Service, Denver, Colorado, USA.

Current Protocols in Pharmacology
|October 4, 2011
PubMed

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G-protein Coupled Receptors

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G-protein Coupled Receptors

G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
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