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Total desmosines in plasma and urine correlate with lung function
C A Lindberg1, G Engström, M Gerhardsson de Verdier
1AstraZeneca R&D, S-221 87 Lund, Sweden. kristina.f.semb@insatnet.nu
The European Respiratory Journal
|October 4, 2011
Summary
Matrix degradation biomarkers, desmosines, show a significant relationship with lung function measures. Urinary desmosines, in particular, may serve as a valuable biomarker for chronic obstructive pulmonary disease (COPD) status.
Area of Science:
- Biochemistry
- Pulmonology
- Biomarker Discovery
Background:
- Matrix degradation biomarkers, including desmosine and isodesmosine (desmosines), are implicated in tissue health.
- Lung function decline is a hallmark of various respiratory diseases, necessitating reliable diagnostic markers.
Purpose of the Study:
- To investigate the association between desmosine levels in plasma and urine and lung function parameters.
- To explore the potential of desmosines as biomarkers for chronic obstructive pulmonary disease (COPD).
Main Methods:
- Measurements of plasma and urinary total desmosines (P- and U-desmosines), lung function, and diffusing capacity for carbon monoxide (D(L,CO)) were conducted.
- Data from 349 (U-desmosines) and 318 (P-desmosines) subjects from the Swedish Twin Registry were analyzed.
- Multiple linear regression was used to identify factors associated with U-desmosines, and correlations with lung function were assessed after adjustments.
Main Results:
- Urinary desmosines (U-desmosines) showed significant correlations with all lung function measures in the overall population.
- Plasma desmosines (P-desmosines) were correlated with forced expiratory volume in 1 second and D(L,CO).
- The associations between desmosines and lung function were stronger in subjects with COPD compared to those without.
Conclusions:
- Desmosine levels, especially U-desmosines, are significantly associated with lung function.
- These findings suggest that desmosines hold promise as a potential biomarker for assessing COPD status.
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