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Published on: September 21, 2015
Infectious complications after transrectal ultrasound-guided prostatic biopsy. Analysis of our experience
Natalia Miranda Utrera1, María Blanco Álvarez, José Medina Polo
1Urology Department, Hospital Universitario 12 de Octubre, Madrid, Spain. natipuchi@hotmail.com
Objectives:
To establish the rate of infectious complications derived from the use of transrectal ultrasound-guided prostate biopsy (TRUS), identify its microbiological profile and related risk factors.
Methods:
We designed a prospective non-randomized study in which we enrolled 220 patients undergoing TRUS biopsy at our centre between April and September 2008. The inclusion criteria were: suspicious digital rectal examination, PSA >10 ng/ml, and free/total ratio of PSA is assessed in patients with PSA 4-10 ng/ml. The exclusion criteria were: having an indwelling urinary catheter, the administration of antibiotic treatment in the week before the needle biopsy, manipulation of the urinary tract in the month prior to the needle biopsy, allergy to quinolones and risk of endocarditis, failure to comply with the antibiotic prophylaxis regimen and loss to follow-up. We analyzed the relationship between diabetes, immunodepression, previous UTI or prostatitis and positive prebiopsy urine culture with the appearance of fever, dysuria or bacteriuria following needle biopsy.
Results:
Mean age was 69.5 years (+/-7.9), mean total PSA 12.7 ng/ml (+/-28.7), mean prostate volume 50.6 cc (+/-29.6) and mean number of cores obtained by needle biopsy 13.5 (+/-1.7). 25% of the patients had dysuria following needle biopsy, 3.2% fever and 4.5% bacteriuria. E.coli was the pathogen most frequently found in pre- and post-biopsy urine cultures. No statistically significant relationship was found between the appearance of dysuria and fever and being diabetic, having immunosuppression, previous UTI or prostatitis, prostate volume and number of cores obtained in the biopsy. Only the existence of a positive pre-biopsy urine culture and biopsy with more than 14 cores proved to have a statistically significant association with the existence of bacteriuria following biopsy, p=0.007 and p= 0.018, respectively.
Conclusions:
Our rate of infectious complications was similar to that described in other series. The existence of a positive prebiopsy urine culture and obtaining more than 14 cores per biopsy was related, with statistical significance, to the existence of bacteriuria following the biopsy. E.coli was the most frequently isolated pathogen.
Insights
Infectious complications after transrectal ultrasound-guided prostate biopsy (TRUS) are similar to other studies. A positive pre-biopsy urine culture and over 14 cores increase bacteriuria risk.
Area of Science:
- Urology
- Infectious Diseases
- Oncology
Background:
- Transrectal ultrasound-guided prostate biopsy (TRUS) is a common procedure for diagnosing prostate cancer.
- Infectious complications following TRUS biopsy can lead to patient morbidity and impact treatment decisions.
- Understanding the incidence, microbiological profile, and risk factors for these complications is crucial for improving patient safety.
Purpose of the Study:
- To determine the rate of infectious complications associated with TRUS biopsy.
- To identify the common pathogens involved in post-biopsy infections.
- To investigate risk factors, such as pre-existing conditions and procedural elements, that may predispose patients to infectious complications.
Main Methods:
- A prospective, non-randomized study enrolled 220 patients undergoing TRUS biopsy.
- Patients were selected based on specific criteria including suspicious digital rectal examination or PSA levels.
- Exclusion criteria included recent antibiotic use, urinary tract manipulation, and antibiotic allergies.
Main Results:
- The study reported rates of dysuria (25%), fever (3.2%), and bacteriuria (4.5%) post-biopsy.
- Escherichia coli (E.coli) was the most frequently identified pathogen in urine cultures.
- No significant association was found between complications like fever or dysuria and factors such as diabetes or immunosuppression.
Conclusions:
- The incidence of infectious complications in this TRUS biopsy series was comparable to existing literature.
- A positive pre-biopsy urine culture and performing more than 14 biopsy cores were significantly associated with an increased risk of post-biopsy bacteriuria.
- E.coli remains the predominant pathogen causing urinary tract infections after prostate biopsy.
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