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Updated: May 28, 2026
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Published on: November 29, 2019
Cytokine mapping in cerebrospinal fluid and blood in multiple sclerosis patients without oligoclonal bands
M Vrethem1, M Kvarnström, J Stenstam
1Department of Neurology, Division of Neuroscience, Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden. magnus.vrethem@lio.se
Objective:
Since there are clinical and genetic differences between MS patients with intrathecal oligoclonal bands (OCB+) in the cerebrospinal fluid (CSF) compared with those without (OCB-), the aim was to find out if OCB- patients showed a different pattern of cytokine immune activation compared with OCB+ patients.
Methods:
The study included 25 MS patients (10 OCB- and 15 OCB+) and 13 controls. A panel of cytokines was measured; IL-1β, IL-6, IL-8/CXCL8, IL-10, TNF and GM-CSF in serum, CSF and in supernatants from polyclonally stimulated blood mononuclear cells, where also levels of IL-12p40, IL-13, IL-15, IL-17 and IFN-γ were measured. The concentrations of soluble (s) VCAM-1 and sCD14 were measured in serum and CSF.
Results:
In general, there were no extensive differences in cytokine concentrations between the OCB- and OCB+ groups.
Conclusion:
OCB- MS patients do not seem to constitute a separate entity concerning inflammatory parameters measured as cytokine concentrations in CSF and blood.
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