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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
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Published on: July 19, 2019

Cortical dysfunction underlies disability in multiple sclerosis.

Steve Vucic1, Therese Burke, Kerry Lenton

  • 1Sydney Medical School Westmead, University of Sydney, Australia. s.vucic@neura.edu.au

Multiple Sclerosis (Houndmills, Basingstoke, England)
|October 4, 2011
PubMed
Summary
This summary is machine-generated.

Cortical dysfunction is evident in secondary progressive multiple sclerosis (SPMS), impacting motor evoked potentials and intracortical inhibition. These changes correlate with disease severity, suggesting a role in quantifying MS progression.

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Published on: September 21, 2021

Area of Science:

  • Neuroscience
  • Neurology
  • Clinical Neurophysiology

Background:

  • Gray matter atrophy is linked to secondary progressive multiple sclerosis (SPMS).
  • Cortical function assessment using transcranial magnetic stimulation (TMS) is crucial for understanding SPMS pathophysiology.

Purpose of the Study:

  • To investigate cortical dysfunction in SPMS using novel paired-pulse threshold tracking TMS techniques.
  • To determine if cortical dysfunction is a characteristic feature of SPMS.

Main Methods:

  • Cortical excitability was studied in 15 SPMS patients, 25 relapsing-remitting MS (RRMS) patients, and 66 controls.
  • Paired-pulse threshold tracking TMS techniques were employed.

Main Results:

  • SPMS patients exhibited reduced short interval intracortical inhibition and motor evoked potential (MEP) amplitude.
  • Increased intracortical facilitation and resting motor threshold were observed in SPMS patients.
  • Prolonged central motor conduction time was noted in SPMS and RRMS patients, correlating with disability.

Conclusions:

  • Cortical dysfunction is associated with disability in multiple sclerosis (MS).
  • Quantifying cortical dysfunction may help in assessing MS disease severity.