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Progression of coronary artery calcification in renal transplant recipients

Nurhan Seyahi1, Deniz Cebi, Mehmet R Altiparmak

  • 1Department of Internal Medicine, Division of Nephrology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey. nseyahi@yahoo.com

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
|October 4, 2011
PubMed

Insights

Coronary artery calcification (CAC) progresses in most kidney transplant recipients, increasing cardiac risk. Baseline CAC, high triglycerides, and bisphosphonate use are key factors associated with this progression.

Area of Science:

  • Nephrology
  • Cardiology
  • Radiology

Background:

  • Cardiovascular disease is the primary cause of death in renal transplant recipients.
  • Coronary artery calcification (CAC) progression predicts cardiac risk in the general population.
  • Understanding CAC progression in transplant patients is crucial for risk stratification.

Purpose of the Study:

  • To determine the progression of coronary artery calcification (CAC) in renal transplant recipients.
  • To identify factors associated with CAC progression.
  • To assess the impact of different analytical methods on CAC progression evaluation.

Main Methods:

  • Multi-detector computed tomography (MDCT) used for CAC assessment in 150 prevalent renal transplant recipients without prior cardiovascular disease.
  • Baseline and follow-up scans (average 2.8 years) evaluated for changes in CAC scores.
  • Multivariate logistic regression analyzed determinants of CAC progression.

Main Results:

  • Baseline CAC prevalence was 35.3%, increasing to 64.6% at follow-up.
  • Mean CAC score increased from 60.0 to 94.9.
  • CAC progression incidence ranged from 28.0% to 38.0% based on definition; independent determinants included baseline CAC, high triglycerides, and bisphosphonate use.

Conclusions:

  • Renal transplantation does not halt or reverse coronary artery calcification (CAC).
  • CAC progression is the typical outcome in renal transplant recipients.
  • Baseline CAC, elevated triglycerides, and bisphosphonate use are linked to CAC progression.
Abstract

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