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Lower serum total testosterone is associated with lymph node metastases in a radical prostatectomy cohort study
Christian Kratzik1, Irene Womastek, Christian Bieglmayer
1Department of Urology, Medical University of Vienna, Allgemeines Krankenhaus, Wien 1090, Währinger Gürtel 18-20, Austria. christian.kratzik@meduniwien.ac.at
Background:
Data on testosterone levels of patients with prostate cancer of different grade and stage are inconsistent. We retrospectively investigated serum total testosterone of a radical prostatectomy cohort to further shed light on this problem.
Patients And Methods:
The preoperative level of serum total testosterone of 217 patients (mean age: 65±5.8 years) undergoing radical prostatectomy between 1989 and 2002 was analyzed for possible associations with Gleason score (≤6 vs. <7 vs. 8-10) and tumor stage (pT2 vs. pT3 vs. N+) with adjustment for age, diabetes and obesity. Patients exhibiting prostate-specific antigen (PSA) levels of >10 ng/ml and biopsy Gleason scores of ≥7 were submitted to standard lymphadenectomy.
Results:
The multivariate model revealed a significant effect of body mass index (BMI) (p=0.0003) and diabetes (p=0.002) on testosterone levels. Significantly lower testosterone levels were recorded in patients with nodal metastases (p<0.0001) compared to patients with non metastatic disease. No significant associations between testosterone, Gleason score and stage were found in patients with non- metastatic disease.
Conclusion:
Testosterone levels prior to radical prostatectomy were lower in patients with nodal involvement.
