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Capillary TSH screening programme for Down's syndrome in Scotland, 1997-2009
Sheena McGowan1, Jeremy Jones, Arlene Brown
1Department of Child Health, Royal Hospital for Sick Children, Yorkhill, Glasgow, UK.
Archives of Disease in Childhood
|October 4, 2011
Summary
Annual thyroid stimulating hormone (TSH) screening is feasible for children with Down's syndrome. Early detection and treatment of thyroid dysfunction are crucial for this population.
Area of Science:
- Endocrinology
- Genetics
- Pediatrics
Background:
- Down's syndrome is associated with a higher risk of thyroid dysfunction.
- Early detection and management of hypothyroidism are essential for developmental outcomes.
Purpose of the Study:
- To evaluate the effectiveness and feasibility of community-based capillary TSH screening in Scotland for children with Down's syndrome.
- To establish optimal screening frequency and treatment strategies.
Main Methods:
- Capillary TSH levels were measured in children aged 1-19 years with Down's syndrome.
- Clinical and biochemical data were collected via proformas between 1997 and 2009.
Main Results:
- Over 5700 tests were performed on 1329 children, showing increasing uptake over time.
- A prevalence of at least 5.7% for thyroid dysfunction was identified.
- Two preschool children presented with severe hypothyroidism.
Conclusions:
- Community-based capillary TSH screening is highly feasible for children with Down's syndrome.
- Annual screening from one year of age is recommended.
- Thyroxine treatment is indicated for TSH levels ≥ 11.0 mU/l, while TSH 6-10 mU/l warrants initial surveillance.
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