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Trihexyphenidyl dependence-report of two cases.
A Michael1, T Murali, P J Mathai
1Junior Resident, Department of Psychiatry, National Institute of Mental Health & Neuro Sciences, Bangalore-560 029.
Indian Journal of Psychiatry
|October 4, 2011
Summary
This report details two instances of normal dose dependence on Trihexyphenidyl, a medication used for Parkinson's disease. It also reviews existing literature on the abuse and dependence associated with anti-parkinsonian drugs.
Area of Science:
- Neurology
- Pharmacology
- Addiction Medicine
Background:
- Trihexyphenidyl is an anticholinergic drug commonly prescribed for Parkinson's disease symptoms.
- Abuse and dependence on anti-parkinsonian medications, including Trihexyphenidyl, are recognized clinical concerns.
- Understanding dose-dependent dependence is crucial for patient safety and treatment adherence.
Purpose of the Study:
- To report two cases of normal dose dependence on Trihexyphenidyl.
- To review the existing literature concerning the abuse and dependence of anti-parkinsonian drugs.
- To contribute to the understanding of Trihexyphenidyl's dependence potential.
Main Methods:
- Case report analysis.
- Literature review of anti-parkinsonian drug abuse and dependence.
Main Results:
- Two cases demonstrating dependence on Trihexyphenidyl at standard therapeutic doses were identified.
- The review highlighted patterns and risk factors associated with anti-parkinsonian drug abuse and dependence.
Conclusions:
- Trihexyphenidyl can lead to dependence even at normal therapeutic doses.
- Clinicians should be vigilant for signs of dependence in patients using anti-parkinsonian drugs.
- Further research into the mechanisms and prevalence of dependence is warranted.
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