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Isoniazid induced claustrophobia-a case report.
C E Prasad1, K Krishnamurthy, T Srinivasulu
1P.G. Student, Hospital for Diseases of Chest & Tuberculosis, Hyderabad.
Indian Journal of Psychiatry
|October 4, 2011
Summary
This case report details claustrophobia in a tuberculosis patient on antitubercular drugs. Isoniazid was identified as the likely cause, as symptoms reappeared upon its reintroduction.
Area of Science:
- Neuropsychiatry
- Pharmacology
- Infectious Diseases
Background:
- Tuberculosis (TB) treatment involves long-term antitubercular drug regimens.
- Isoniazid is a primary drug in TB treatment, known for potential neuropsychiatric side effects.
- Phobic neurosis is a recognized psychiatric condition, but its association with specific TB drugs is less documented.
Purpose of the Study:
- To report a rare case of claustrophobia potentially induced by isoniazid in a tuberculosis patient.
- To highlight the need for vigilance regarding uncommon side effects of antitubercular medications.
- To contribute to the understanding of isoniazid's neuropsychiatric adverse effects.
Main Methods:
- Case report of a 45-year-old male tuberculosis patient.
- Clinical observation of symptom onset after 18 months of antitubercular therapy.
- Diagnostic assessment involving drug reintroduction and withdrawal, including isoniazid (INH).
Main Results:
- The patient developed significant claustrophobia during antitubercular therapy.
- Claustrophobic symptoms recurred upon reintroduction of isoniazid-containing regimens.
- Symptoms resolved when isoniazid was discontinued, with no recurrence on a non-isoniazid regimen.
Conclusions:
- Isoniazid is implicated as the probable cause of claustrophobia in this patient.
- This case suggests phobic neurosis as a potential, previously unreported, neuropsychiatric side effect of isoniazid.
- Clinicians should consider isoniazid-induced phobic neurosis in tuberculosis patients presenting with similar symptoms.
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