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Related Experiment Video

Updated: May 28, 2026

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
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A SPECT Camera for Combined MRI and SPECT for Small Animals.

D Meier1, D J Wagenaar, S Chen

  • 1Gamma Medica - Ideas (Norway) AS, Martin Linges Vei 25, Snarøya, POB 1, N-1330 Fornebu, Norway.

Nuclear Instruments & Methods in Physics Research. Section A, Accelerators, Spectrometers, Detectors and Associated Equipment
|October 4, 2011
PubMed
Summary

Researchers developed a novel, Magnetic Resonance (MR)-compatible Single Photon Emission Computed Tomography (SPECT) camera for simultaneous in-vivo imaging in mice. This breakthrough enables combined functional and anatomical imaging, overcoming previous interference issues between MR and SPECT technologies.

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Area of Science:

  • Medical Imaging
  • Biomedical Engineering
  • Nuclear Medicine

Background:

  • Conventional Single Photon Emission Computed Tomography (SPECT) systems cannot operate within Magnetic Resonance Imaging (MRI) scanners due to mutual interference.
  • Simultaneous acquisition of functional (SPECT) and anatomical (MRI) data in small animals is highly desirable for research.
  • Existing technologies limit the integration of SPECT and MRI for in-vivo small animal studies.

Purpose of the Study:

  • To develop and evaluate an MR-compatible SPECT camera system for simultaneous in-vivo imaging in small animals.
  • To enable combined functional and anatomical imaging in mice within a single MRI system.
  • To overcome the limitations of conventional SPECT-MRI interference.

Main Methods:

  • Designed and assembled a prototype MR-compatible SPECT camera system utilizing semiconductor radiation sensors (CZT, ASICs).

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  • Integrated the SPECT camera into a state-of-the-art MRI system with a minimum 12-cm bore size.
  • Utilized an MR-compatible multi-pinhole collimator with a ø25-mm field-of-view for mice.
  • Acquired SPECT and MRI data from radioactive sources and resolution phantoms both inside and outside the MRI.

    • Main Results:

    • The prototype SPECT camera system was successfully assembled and tested.
    • Simultaneous SPECT and MRI data acquisition was demonstrated in-vivo in mice.
    • The system demonstrated compatibility within a high-field MRI environment without significant interference.
    • The SPECT camera achieved functional imaging capabilities alongside anatomical MRI data.

    Conclusions:

    • A novel MR-compatible SPECT camera has been developed, enabling simultaneous in-vivo imaging in small animals.
    • This technology overcomes previous limitations of SPECT-MRI interference, paving the way for advanced multimodal imaging research.
    • The system provides complementary functional and anatomical information, enhancing the study of biological processes in mice.