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Related Experiment Videos

Anticonvulsants in affective disorders.

J G Small1

  • 1Department of Psychiatry, Indiana University School of Medicine, Larue D. Carter Memorial Hospital, Indianapolis 46202.

Psychopharmacology Bulletin
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

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Anticonvulsant drugs like carbamazepine show effectiveness in managing mania and depression, offering alternatives to traditional treatments. Further research is needed for other anticonvulsants in affective disorders.

Area of Science:

  • Psychiatry and Pharmacology
  • Neuroscience
  • Clinical Therapeutics

Background:

  • Affective disorders, including mania and depression, present significant treatment challenges.
  • Anticonvulsant drugs are increasingly explored as therapeutic options for these conditions.
  • Established treatments like lithium and electroconvulsive therapy (ECT) have limitations and side effects.

Purpose of the Study:

  • To evaluate the current status and efficacy of anticonvulsant drugs in managing affective disorders.
  • To compare anticonvulsants with established treatments such as lithium, neuroleptics, and ECT.
  • To identify established and experimental roles for anticonvulsants in treating mania, depression, and prophylaxis.

Main Methods:

  • Review and synthesis of data from controlled clinical studies.

Related Experiment Videos

  • Comparative analysis of anticonvulsant efficacy against placebo, neuroleptics, lithium, and ECT.
  • Assessment of evidence for carbamazepine, valproate, clonazepam, lorazepam, and alprazolam in affective disorders.

    • Main Results:

    • Carbamazepine demonstrates superiority over placebo, equivalence to neuroleptics, and comparability to lithium for mania in treatment-refractory patients.
    • Carbamazepine shows potential as an antidepressant and for prophylaxis.
    • Valproate and clonazepam show promise for mania and prophylaxis, but require more research.
    • Benzodiazepines like lorazepam may be useful antimanic agents, and alprazolam has antidepressant effects.
    • Electroconvulsive therapy (ECT) is effective for both mania and depression.

    Conclusions:

    • Carbamazepine and ECT are established treatments for mania, while ECT is established for depression.
    • Valproate and clonazepam are experimental for mania and maintenance treatment.
    • Carbamazepine and alprazolam are experimental for depression.
    • Combinations of anticonvulsants with lithium show promise but need further investigation.
    • The role of other anticonvulsants in affective disorders remains undetermined.