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Updated: May 28, 2026

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
[Ocular changes after hormone replacement therapy in postmenopausal women. A preliminary report]
Sebastián Carranza Lira1, Alicia M Jiménez, Irene Olhovich
1Departamento de Ginecología Endocrina, Hospital de Ginecología y Obstetricia Luis Castelazo Ayala, Instituto Mexicano del Seguro Social, México, DF. scarranzal@mexis.com
Background:
Ocular function is modified with hormone therapy; however, reports in literature are highly controversial.
Objective:
To analyze how hormone therapy modifies intraocular pressure and the number of tears shed by Mexican women.
Patients And Methods:
Eighteen postmenopausal women were studied and randomly divided into two groups, according to the treatment they received: group 1, conjugated equine estrogens (CEE) 0.625 mg/day (n=9) (hysterectomized women with bilateral oophorectomy) and group 2, CEE 0.625 mg/day plus chlormadinone 1 mg/day (n=9) (women with intact uterus). Changes in intraocular pressure and Schirmer's test were analyzed at baseline and three months after the treatment. Statistical analysis was performed with Student's t test for independent and paired samples.
Results:
There were no significant differences in intraocular pressure or Schirmer's test among groups, neither when comparing baseline and final results in each group independently.
Conclusion:
We could not demonstrate the effect of hormone replacement therapy on intraocular pressure and on Schirmer's test after three months of its administration.
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