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Stable Isotope In-Vivo Labeling for Mass-Spectrometry Identification of Paternal Metabolites Transferred from Sperm to Oocyte During Fertilization
Published on: June 17, 2025
[Probable association between preeclampsia/eclampsia and paternal age: a pilot study]
Liliana García-Ortiz1, José Gutiérrez-Salinas, Carlos Galaviz-Hernández
1Laboratorio de Medicina Genómica, Centro Médico Nacional 20 de Noviembre, ISSSTE, México. garortiz@yahoo.com
Ginecologia Y Obstetricia De Mexico
|October 5, 2011
Summary
Paternal age may influence preeclampsia risk. Men in preeclamptic pregnancies showed greater age variance compared to controls, suggesting a potential link between paternal age and preeclampsia development.
Area of Science:
- Reproductive Medicine
- Genetics
- Obstetrics
Background:
- Preeclampsia is a leading cause of maternal and fetal mortality globally.
- Both maternal and paternal factors contribute to preeclampsia risk.
Purpose of the Study:
- To investigate the association between paternal age and preeclampsia.
- To determine if paternal age variance differs in preeclamptic versus normotensive pregnancies.
Main Methods:
- Analysis of preeclampsia-eclampsia patients and couples against a control group of normal pregnancies.
- Utilized the "National High Blood Pressure Education Program Working Group" classification.
- Statistical analysis of age variance in paternal age groups.
Main Results:
- 27 mild preeclampsia cases, 13 severe preeclampsia cases, and 40 controls were analyzed.
- Men in the preeclamptic group exhibited significantly greater age variance than men in the control group (p < 0.001).
Conclusions:
- Paternal age may play a role in preeclampsia etiology.
- Potential mechanisms include paternal-maternal imprinting, sperm senescence, and telomere shortening.
- Further research is needed to elucidate the precise role of paternal age in preeclampsia.
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