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[Probable association between preeclampsia/eclampsia and paternal age: a pilot study]
Liliana García-Ortiz1, José Gutiérrez-Salinas, Carlos Galaviz-Hernández
1Laboratorio de Medicina Genómica, Centro Médico Nacional 20 de Noviembre, ISSSTE, México. garortiz@yahoo.com
Insights
Paternal age may influence preeclampsia risk. Men in preeclamptic pregnancies showed greater age variance compared to controls, suggesting a potential link between paternal age and preeclampsia development.
Area of Science:
- Reproductive Medicine
- Genetics
- Obstetrics
Background:
- Preeclampsia is a leading cause of maternal and fetal mortality globally.
- Both maternal and paternal factors contribute to preeclampsia risk.
Purpose of the Study:
- To investigate the association between paternal age and preeclampsia.
- To determine if paternal age variance differs in preeclamptic versus normotensive pregnancies.
Main Methods:
- Analysis of preeclampsia-eclampsia patients and couples against a control group of normal pregnancies.
- Utilized the "National High Blood Pressure Education Program Working Group" classification.
- Statistical analysis of age variance in paternal age groups.
Main Results:
- 27 mild preeclampsia cases, 13 severe preeclampsia cases, and 40 controls were analyzed.
- Men in the preeclamptic group exhibited significantly greater age variance than men in the control group (p < 0.001).
Conclusions:
- Paternal age may play a role in preeclampsia etiology.
- Potential mechanisms include paternal-maternal imprinting, sperm senescence, and telomere shortening.
- Further research is needed to elucidate the precise role of paternal age in preeclampsia.
Background:
The preeclampsia is a multisystemic syndrome that occupied the first cause of maternal and fetal mortality around the world. Epidemiologic studies shown both mother and father contribute at the same risk for preeclampsia.
Objective:
To determinate if there is an association between preeclampsia and paternal age.
Material And Method:
Preeclampsia-eclampsia patients and couples were analyzed in agree to "National High Blood Pressure Education Program Working Group" classification, and a control group constituted by normal pregnant women and couples was included.
Results:
There were 27 cases with mild preeclampsia and her couples, 13 cases with severe preeclampsia and her couples and 40 controls conformed by normal pregnant women and her couples. The statistical analysis of variance of the ages shown that men from preeclamptic group had a greater variance in contrast with man of control group (p < 0.001; valor of F = 5.084).
Conclusions:
Although is not clear how paternal age interview in preeclampsia risk, the interaction between paternal-maternal imprinting and spermatic senescence, followed by shortened telomeres of chromosome, could be produce the inactivity of a whole network of signals implicated in disease aetiology.
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