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Updated: Aug 3, 2026

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Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
Published on: May 29, 2020
Disulfiram-induced hepatitis
1Veterans Affairs Medical Center, Medicine Service, Johnson City, TN 37684.
Southern Medical Journal
|July 1, 1990
Summary
Disulfiram therapy can cause drug-induced liver injury, presenting with symptoms like fever and rash. Prompt discontinuation of disulfiram leads to recovery of liver function.
Area of Science:
- Hepatology
- Clinical Toxicology
Background:
- Disulfiram is a medication used to deter alcohol consumption.
- Drug-induced liver injury (DILI) is a significant concern with various medications.
Observation:
- A patient developed headache, fever, nausea, vomiting, rash, and eosinophilia after three weeks of disulfiram treatment.
- Liver biopsy revealed low-grade lobular hepatitis.
Findings:
- Disulfiram-induced hepatitis presented with unique clinical features in this case.
- Cessation of disulfiram therapy resulted in symptom resolution and normalization of liver function tests.
Implications:
- This case highlights the importance of considering disulfiram in the differential diagnosis of drug-induced liver injury.
- Early recognition and withdrawal of the offending agent are crucial for managing disulfiram hepatotoxicity.
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