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Systemic Torulopsis glabrata infection in a neonate
E B Walter1, J L Gingras, R E McKinney
1Department of Pediatrics, Duke University Medical Center, Durham, NC 27710.
Southern Medical Journal
|July 1, 1990
Summary
Neonatal peritonitis and ventriculitis caused by Torulopsis glabrata, linked to a ventriculoperitoneal shunt, were successfully treated. Antifungal therapy with amphotericin B and 5-fluorocytosine resolved the fungemia and central nervous system infection.
Area of Science:
- Neonatal Medicine
- Infectious Diseases
- Neurosurgery
Background:
- Ventriculoperitoneal shunts are crucial for managing hydrocephalus in neonates.
- Shunt-associated infections pose significant risks, including fungemia and central nervous system involvement.
- Torulopsis glabrata (Candida glabrata) is an opportunistic fungal pathogen that can cause severe infections.
Observation:
- A case of neonatal Torulopsis glabrata peritonitis and ventriculitis is presented.
- The infection was associated with the presence of a ventriculoperitoneal shunt.
- Clinical presentation included signs of both abdominal and central nervous system infection.
Findings:
- Successful treatment of fungemia and ventriculitis was achieved.
- Combination antifungal therapy using amphotericin B and 5-fluorocytosine was employed.
- The treatment regimen effectively eradicated the fungal pathogens.
Implications:
- This case highlights the importance of considering fungal etiologies in shunt-associated infections in neonates.
- Prompt and appropriate antifungal treatment is critical for favorable outcomes.
- Vigilance for fungal infections in neonates with ventriculoperitoneal shunts is warranted.