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Reduced bone mineral density in hypertensive patients is associated with left ventricular diastolic dysfunction, not

Hisashi Masugata1, Shoichi Senda, Koji Murao

  • 1Department of Integrated Medicine, Kagawa University, Kagawa, Japan. masugata@med.kagawa-u.ac.jp

Clinical and Experimental Hypertension (New York, N.Y. : 1993)
|October 5, 2011
PubMed

Insights

Reduced bone mineral density in hypertensive patients is linked to diastolic dysfunction, not left ventricular hypertrophy. This association suggests an increased risk for heart failure and bone fractures in this population.

Area of Science:

  • Cardiology
  • Bone Metabolism

Background:

  • Hypertension is frequently associated with left ventricular (LV) hypertrophy and diastolic dysfunction, risk factors for heart failure.
  • Reduced bone mineral density (BMD) has been observed in hypertensive individuals, but its relationship with cardiac abnormalities is unclear.

Purpose of the Study:

  • To investigate the association between bone mineral density and LV hypertrophy and diastolic dysfunction in hypertensive patients.

Main Methods:

  • Bone mineral density of the calcaneus was measured using quantitative ultrasound (stiffness index).
  • Left ventricular mass index (LVMI) assessed LV hypertrophy via echocardiography.
  • Left ventricular diastolic function evaluated using early diastolic mitral annular velocity (e') and E/e' ratio.

Main Results:

  • No significant correlation was found between bone mineral density and LVMI.
  • Bone mineral density showed a positive correlation with e' (r = 0.453, P < .01).
  • Bone mineral density demonstrated a negative correlation with E/e' (r = -0.359, P < .05).

Conclusions:

  • Reduced bone mineral density in hypertensive patients is associated with LV diastolic dysfunction, not LV hypertrophy.
  • Hypertensive patients with low BMD may face elevated risks of heart failure due to diastolic dysfunction and osteoporosis-related fractures.

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