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Seasonal and weekly patterns of occurrence of acute cardiovascular diseases: does a gender difference exist?

Roberto Manfredini1, Fabio Fabbian, Marco Pala

  • 1Department of Clinical and Experimental Medicine, University of Ferrara, Via Savonarola 9, Ferrara, Italy. roberto.manfredini@unife.it

Journal of Women'S Health (2002)
|October 5, 2011
PubMed

Insights

Cardiovascular events show seasonal peaks in winter and weekly peaks on Mondays, regardless of gender. This study found no differences in these temporal patterns between men and women for acute cardiovascular events.

Area of Science:

  • Cardiology
  • Chronobiology
  • Epidemiology

Background:

  • Cardiovascular disease (CV) is the leading cause of mortality in women.
  • Acute CV events exhibit known seasonal and weekly onset patterns.
  • This study investigated potential gender differences in these temporal patterns.

Purpose of the Study:

  • To determine if seasonal and weekly patterns of acute cardiovascular events differ between genders.
  • To analyze temporal trends in hospital admissions for various CV events.

Main Methods:

  • Analysis of cumulative hospital admission data (1998-2006) for acute myocardial infarction (AMI), stroke, transient ischemic attack (TIA), aortic diseases (AD), and pulmonary embolism (PE).
  • Statistical testing for uniformity of monthly and daily event distributions using the chi-square test.
  • Application of chronobiologic methods for seasonal rhythmic analysis of event data.

Main Results:

  • Seasonal distribution showed peaks in January and winter, with no observed gender differences.
  • Weekly distribution revealed a peak on Mondays, irrespective of gender.
  • Multivariate regression analysis confirmed no gender-based differences in temporal event distribution, even after accounting for risk factors and age.

Conclusions:

  • The occurrence of cardiovascular events demonstrates seasonal and day-of-week patterns.
  • These temporal patterns of cardiovascular events appear to be independent of gender.
Abstract

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