Meta-analysis: hyperhomocysteinaemia in inflammatory bowel diseases
A Oussalah1, J-L Guéant, L Peyrin-Biroulet
1INSERM U954, Cellular and Molecular Pathology in Nutrition, Henri Poincaré University Nancy 1, and University Hospital of Nancy, Vandoeuvre-lès-Nancy, France.
Patients with inflammatory bowel diseases (IBD) have significantly higher homocysteine levels and a greater risk of hyperhomocysteinaemia compared to healthy individuals. Further research is needed to clarify the link between hyperhomocysteinaemia and thrombosis in IBD patients.
Area of Science:
- Gastroenterology
- Metabolic Medicine
- Clinical Research
Background:
- The relationship between homocysteine metabolism and inflammatory bowel diseases (IBD) is not fully understood.
- The association between hyperhomocysteinaemia and thrombosis in IBD patients is debated.
Purpose of the Study:
- To systematically review and analyze the association between homocysteine levels and IBD.
- To investigate the risk of hyperhomocysteinaemia and its link to thrombosis in IBD.
Main Methods:
- A systematic literature search was conducted using MEDLINE and conference abstracts from January 1966 to April 2011.
- Included studies evaluated plasma homocysteine levels in IBD patients.
Main Results:
- IBD patients exhibited significantly higher plasma homocysteine levels (WMD=3.75 μmol/L) and increased risk of hyperhomocysteinaemia (OR=4.65) compared to controls.
- No significant difference in homocysteine levels was observed between ulcerative colitis and Crohn's disease.
- Hyperhomocysteinaemia risk was not elevated in IBD patients with thromboembolic complications (OR=1.97).
- Lower plasma folate levels correlated with increased IBD risk related to MTHFR C677T polymorphism.
Conclusions:
- Individuals with IBD have a substantially higher risk of hyperhomocysteinaemia.
- The role of hyperhomocysteinaemia in IBD-related thrombosis warrants additional investigation.
- Folate deficiency exacerbates the impact of MTHFR C677T polymorphism on IBD risk.
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