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Related Experiment Videos

Plasma histamine levels in polytraumatized patients.

M Ennis1, M Sangmeister, E Neugebauer

  • 1Institute for Theoretical Surgery, Clinic of the Philipps University Marburg, FRG.

Agents and Actions
|April 1, 1990
PubMed
Summary

Elevated plasma histamine levels in polytrauma patients indicate a poor prognosis. Higher histamine levels on days 1 and 5 post-trauma correlated with mortality, suggesting its use as a prognostic marker.

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Area of Science:

  • Trauma Care
  • Clinical Biochemistry
  • Immunology

Background:

  • Polytrauma patients exhibit complex physiological responses.
  • Histamine is a key mediator in inflammatory and allergic reactions.
  • Prognostic markers for polytrauma outcomes are crucial for clinical management.

Purpose of the Study:

  • To investigate plasma histamine levels in polytrauma patients.
  • To determine the correlation between plasma histamine levels and patient outcomes.
  • To assess histamine as a potential prognostic factor in severe trauma.

Main Methods:

  • Prospective clinical trial involving 28 polytrauma patients.
  • Measurement of plasma histamine levels on days 1, 5, and 14 post-trauma.
  • Comparison of histamine levels between polytrauma patients and control groups (single trauma, pre-surgery).

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Main Results:

  • Median plasma histamine levels were significantly higher in polytrauma patients compared to controls.
  • All patients with plasma histamine levels >1 ng/ml on days 1 and 5 died.
  • All patients with plasma histamine levels >0.5 ng/ml on day 1 died.

Conclusions:

  • Elevated plasma histamine levels are associated with increased mortality in polytrauma.
  • Plasma histamine levels serve as a significant prognostic indicator for adverse outcomes in severe trauma.
  • Histamine elevation, regardless of cause, predicts a poor prognosis in polytrauma patients.