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Accelerometry is associated with walking mobility, not physical activity, in persons with multiple sclerosis.

Madeline Weikert1, Yoojin Suh, Abbi Lane

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Accelerometers in multiple sclerosis (MS) primarily measure walking mobility, not general physical activity. This study found accelerometer data strongly correlated with mobility tests in MS patients, unlike in healthy controls.

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Area of Science:

  • Biomedical Engineering
  • Rehabilitation Science
  • Neurology

Background:

  • Accelerometers are widely used to assess real-world mobility.
  • Objective measures are crucial for understanding mobility in neurological disorders like multiple sclerosis (MS).
  • Verifying accelerometer specificity in MS requires comparison with control groups.

Purpose of the Study:

  • To compare accelerometer output with objective mobility measures and physical activity questionnaires in persons with MS and healthy controls.
  • To determine if accelerometers specifically reflect walking mobility or broader physical activity in MS.
  • To validate the use of accelerometers as a measure of mobility in MS.

Main Methods:

  • Sixty-six participants (33 MS, 33 controls) underwent mobility assessments (6-minute walk, Timed-Up-and-Go).
  • Participants wore accelerometers for 7 days and completed physical activity questionnaires (GLTEQ, IPAQ).
  • Statistical analyses, including correlation and regression, were used to compare accelerometer data with mobility and physical activity measures.

Main Results:

  • In MS patients, accelerometer output strongly correlated only with mobility measures (6MW, TUG).
  • In controls, accelerometers correlated with both mobility and physical activity measures (GLTEQ, IPAQ).
  • Regression analysis showed the 6-minute walk test explained significant variance in accelerometer output for MS patients.

Conclusions:

  • Accelerometer data in persons with MS appears to specifically reflect real-world walking mobility.
  • Findings suggest accelerometers may not capture general physical activity in MS, differentiating it from control populations.
  • This supports the targeted use of accelerometers for assessing mobility impairments in MS.