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Updated: May 28, 2026

Differentiation and Imaging of Brown Adipocytes from the Stromal Vascular Fraction of Interscapular Adipose Tissue from Newborn Mice
Published on: February 3, 2023
Involvement of brown adipose tissue in subcutaneous fat necrosis of the newborn
H Ichimiya1, S Arakawa, T Sato
1Department of Dermatology, Oita Prefectural Hospital, Faculty of Medicine, Oita University, Idaigaoka 1-1, Hasama-machi, Yufu City, Japan.
Background:
Subcutaneous fat necrosis (SCFN) of the newborn is a rare condition that manifests within days after birth. The interscapular region, axillae and shoulders are the most commonly affected sites, corresponding to anatomic sites of brown adipose tissue (BAT) in newborns.
Objective:
We postulated a specific involvement of BAT in SCFN and searched for brown adipocytes at affected sites.
Methods:
Biopsy specimens were immunostained with antibodies against uncoupling protein 1 (UCP-1) and examined by electron microscopy. We also examined BAT by (18)F-fluorodeoxyglucose ((18)F-FDG) positron emission tomography and computed tomography (PET-CT) scanning.
Results:
A few cells in biopsy specimens from two patients bound antibodies against UCP-1, and brown adipocytes were detected at several stages of degeneration. PET-CT scans revealed lower uptake of (18)F-FDG at major sites of SCFN.
Conclusion:
SCFN and BAT can be found at the same sites, suggesting a pathophysiological connection.
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