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Borna disease virus - fact and fantasy
W Ian Lipkin1, Thomas Briese, Mady Hornig
1Center for Infection and Immunity, Columbia University Mailman School of Public Health, 722 W 168th St., 17th Floor, New York, NY 10032, United States. wil2001@columbia.edu
Virus Research
|October 5, 2011
Summary
This review covers Borna disease virus (BDV) history, molecular biology, and epidemiology. Research investigated BDV pathogenesis and its potential role in human diseases.
Area of Science:
- Virology
- Neuroscience
- Molecular Biology
Background:
- Borna disease virus (BDV) was discovered in the late 1980s.
- Early research focused on its molecular characterization and pathogenesis.
- Potential links to human neurological disorders have been investigated.
Purpose of the Study:
- To review the history of Borna disease virus research.
- To summarize the molecular biology and epidemiology of bornaviruses.
- To discuss the pathobiology and potential human health implications of BDV.
Main Methods:
- Literature review of historical and current research on BDV.
- Synthesis of data on viral genetics, replication, and host interactions.
- Epidemiological data analysis and pathobiological studies.
Main Results:
- Comprehensive overview of BDV's scientific journey.
- Detailed examination of viral characteristics and spread.
- Exploration of disease mechanisms and zoonotic potential.
Conclusions:
- Borna disease virus remains a significant subject of virological research.
- Continued investigation is crucial for understanding its role in animal and potentially human health.
- Further research into bornavirus pathogenesis and epidemiology is warranted.
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