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Current status and approaches to developing press-coated chronodelivery drug systems
Shan-Yang Lin1, Yoshiaki Kawashima
1Lab. Pharm. Biopharm., Department of Biotechnology, College of Health Sciences, Yuanpei University, Hsin Chu, Taiwan, Republic of China. sylin@mail.ypu.edu.tw
Summary
Constant drug release can cause issues. Pulsatile drug delivery, mimicking natural body rhythms, enhances efficacy and reduces side effects. Press-coated tablets offer a way to achieve this targeted drug release.
Area of Science:
- Pharmacology
- Drug Delivery Systems
- Chronobiology
Background:
- Traditional controlled-release drugs maintain constant blood concentrations, potentially leading to resistance, tolerability issues, and side effects.
- Human physiology fluctuates significantly over 24 hours due to circadian rhythms, making constant drug delivery suboptimal.
- Pulsatile drug release, mirroring natural hormone secretion patterns, can improve therapeutic outcomes and minimize adverse effects.
Purpose of the Study:
- To review chronopharmaceutical press-coated products, focusing on patient physiological needs.
- To explore the advantages of pulsatile drug delivery systems that align with biological rhythms.
- To provide an overview of press-coating technology for chronotherapy applications.
Main Methods:
- Review of existing literature on biological rhythms, pulsatile hormone secretion, and chronopharmaceuticals.
- Analysis of press-coating techniques for creating programmable lag phases and controlled drug release.
- Compilation of market-available chronopharmaceutical preparations and research articles.
Main Results:
- Press coating is a simple, advantageous technique for developing tablets with programmable lag phases followed by drug release.
- Mimicking circadian rhythms through pulsatile drug delivery can optimize therapeutic effects and reduce toxicity.
- Various press-coated delivery systems and their performance factors have been investigated.
Conclusions:
- Chronopharmaceutical press-coated products offer a patient-centric approach to drug delivery by respecting physiological rhythms.
- Press-coating technology provides a viable method for achieving pulsatile drug release, enhancing treatment efficacy.
- Further research and development in press-coating techniques are needed to address current challenges in chronotherapy.
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