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Updated: May 28, 2026

FISH for Pre-implantation Genetic Diagnosis
Published on: February 23, 2011
Statistical analysis and interpretation of prenatal diagnostic imaging studies, part 3: approach to study design
Katherine R Goetzinger1, Methodius G Tuuli, Anthony O Odibo
1Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO 63110 USA.
Abstract:
A critical step in planning a successful study is choosing the appropriate design to feasibly answer the clinical question at hand. We provide an overview of common study designs, discuss their advantages and disadvantages, and provide practical examples from the prenatal diagnosis and ultrasound literature. In addition, we highlight specific design considerations that need to be built into the analysis of study results.
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