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Updated: May 28, 2026
Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording
Published on: September 1, 2022
An optrode particle geometry to decrease response time
Jamie D Walters1, Elizabeth A H Hall
1Institute of Biotechnology, Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, UK.
Abstract:
A hollow 3 μm sensing microcapsule containing chromoionophores within a 100 nm organosilica shell is reported. This shows a response to an ion step two orders of magnitude faster than 'filled' sensing particles of similar diameter. Incorporation of chromoionophores ETH 5294 and ETH 7061 in the capsule shell is shown with a t(90) response <2 s compared with >15 min for filled particles of similar diameters. This ultrafast geometry is also extended to dual ionophore dye incorporation and preliminary exploration of a FRET-based ratiometric method is examined to extend the pH response range, using a single excitation wavelength.
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