Related Experiment Video
Updated: May 28, 2026
Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury
Published on: May 27, 2022
Biochemical markers analyzed using microdialysis and traumatic brain injury outcomes
A Karathanou1, K Paterakis, M Pakopoulou
1Intensive Care Unit, Achillopoulio General Hospital, Volos, Greece.
Aim:
Traumatic brain injury is a leading cause of disability and mortality among young people. Multiparametric cerebral bedside monitoring is a safe and promising technique for preventing secondary brain damage. The objective of this study was to investigate the usefulness of cerebral microdialysis in predicting the outcomes of patients with traumatic brain injury.
Methods:
Thirty-eight patients (33 males) were included in the study. The GCS on admission was ≤8. The outcome was assessed using the GOS over six months of follow-up.
Results:
Among the patients included, 18 had a favorable outcome (GOS=4.5) and the remaining 20 had an unfavorable outcome. L/P ratio and glycerol concentration were statistically significantly higher in the patients with unfavorable prognosis.
Conclusion:
Biochemical parameters analysed using microdialysis could serve as predictor indexes of clinical outcome several months after the injury.
More Related Videos
Related Concept Videos
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
01:28Traumatic Brain Injury l: Introduction